Correction to “Reversible Lysine Specific Demethylase 1 (LSD1) Inhibitors: A Promising Wrench to Impair LSD1”
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ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to “Reversible Lysine Specific Demethylase 1 (LSD1) Inhibitors: A Promising Wrench Impair LSD1”Xing-Jie DaiXing-Jie DaiMore by Xing-Jie Dai, Ying LiuYing LiuMore Liu, Lei-Peng XueLei-Peng XueMore Xue, Xiao-Peng XiongXiao-Peng XiongMore Xiong, ZhouYing ZhouMore Zhou, Yi-Chao Zheng*Yi-Chao ZhengMore Zhenghttp://orcid.org/0000-0002-2662-3770, and Hong-Min Liu*Hong-Min Liuhttp://orcid.org/0000-0001-6771-9421Cite this: J. Med. Chem. 2021, 64, 9, 6410–6411Publication Date (Web):April 19, 2021Publication History Published online19 April 2021Published inissue 13 May 2021https://doi.org/10.1021/acs.jmedchem.1c00568Copyright © 2021 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views1310Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated reflect usage leading up last few days.Citations number other articles citing this article, calculated Crossref daily. Find more information about citation counts.The Altmetric Attention Score quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence for given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InReddit (1 MB) Get e-Alerts
منابع مشابه
Crystal structure of human histone lysine-specific demethylase 1 (LSD1).
Lysine-specific demethylase 1 (LSD1) was recently identified as the first histone demethylase that specifically demethylates monomethylated and dimethylated histone H3 at K4. It is a component of the CoREST and other corepressor complexes and plays an important role in silencing neuronal-specific genes in nonneuronal cells, but the molecular mechanisms of its action remain unclear. The 2.8-A-re...
متن کاملCatalytic Mechanism Investigation of Lysine-Specific Demethylase 1 (LSD1): A Computational Study
Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, is a flavin-dependent amine oxidase which specifically demethylates mono- or dimethylated H3K4 and H3K9 via a redox process. It participates in a broad spectrum of biological processes and is of high importance in cell proliferation, adipogenesis, spermatogenesis, chromosome segregation and embryonic development. To...
متن کاملAnalysis of the levels of lysine-specific demethylase 1 (LSD1) mRNA in human ovarian tumors and the effects of chemical LSD1 inhibitors in ovarian cancer cell lines
BACKGROUND Lysine-specific demethylase 1 (LSD1, also known as KDM1A and AOF2) is a chromatin-modifying activity that catalyzes the removal of methyl groups from lysine residues in histone and non-histone proteins, regulating gene transcription. LSD1 is overexpressed in several cancer types, and chemical inhibition of the LSD1 activity has been proposed as a candidate cancer therapy. Here, we ex...
متن کاملLysine-specific demethylase 1 (LSD1) destabilizes p62 and inhibits autophagy in gynecologic malignancies
Lysine-specific demethylase 1 (LSD1) - also known as KDM1A - is the first identified histone demethylase. LSD1 is highly expressed in numerous human malignancies and has recently emerged as a target for anticancer drugs. Owing to the presence of several functional domains, we speculated that LSD1 could have additional functions other than histone demethylation. P62 - also termed sequestasome 1 ...
متن کاملRegulation of lipogenic gene expression by lysine-specific histone demethylase-1 (LSD1).
Dysregulation of lipid homeostasis is a common feature of several major human diseases, including type 2 diabetes and cardiovascular disease. However, because of the complex nature of lipid metabolism, the regulatory mechanisms remain poorly defined at the molecular level. As the key transcriptional activators of lipogenic genes, such as fatty acid synthase (FAS), sterol regulatory element-bind...
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ژورنال
عنوان ژورنال: Journal of Medicinal Chemistry
سال: 2021
ISSN: ['0022-2623', '1520-4804']
DOI: https://doi.org/10.1021/acs.jmedchem.1c00568